Flangeless Fittings: The Ultimate Leak-Proof Solution for Chromatography and Lab Tubing Connections

If you work with chromatography systems, GPC, bioanalytical instruments, or nucleic acid synthesizers, you know how frustrating leaky connections can be. A single drop can ruin hours of work and contaminate your results. That’s why more labs are switching to flangeless fittings – the smarter, cleaner way to connect hard tubing.

What Are Flangeless Fittings and Why Do They Matter?

Flangeless fittings consist of a nut and a separate ferrule that grips the tubing without requiring you to flare the tube end. This design delivers a tight, wobble-free seal that prevents both liquid and gas leaks, even under demanding conditions.

Unlike traditional flanged systems, flangeless fittings are easier to install, cause less tubing stress, and provide consistent performance run after run.

Key Benefits of Using Flangeless Fittings in Your Lab

• Zero leaks and no wobble – Maintain reliable pressure and flow.
• Smooth 360° finish – Burr-free and spotless for high-purity applications.
• Long-lasting precision molding – Easy to replace individual parts when needed.
• Non-toxic, odorless materials – Safe for sensitive biological and analytical work.

Material Options: Choose the Right One for Your Application

Different lab environments demand different material properties. Here’s a quick guide:

• PP (Polypropylene) – Cost-effective, resistant to most acids, bases, and solvents. Best for general use up to 120°C.
• PEEK (Polyether Ether Ketone) – Exceptional strength and chemical resistance; handles temperatures over 250°C long-term. Ideal for aggressive solvents.
• PVDF (Polyvinylidene Fluoride) – Excellent UV and radiation resistance, FDA-compliant, stable up to 150°C.
• ETFE Ferrules – Outstanding chemical resistance and wide temperature range (-80°C to 150°C).

Compatible Tubing Sizes

Our flangeless fittings support the most common hard tubing outer diameters: 1.6 mm, 2.0 mm, 2.5 mm, 3.0 mm, and 3.2 mm (standard 1/16" equivalents).

Common Applications

• Gel Permeation Chromatography (GPC/SEC)
• Bioanalytical systems and pre-MS tubing
• Nucleic acid and gene synthesizers
• General laboratory chromatography setups

Final Thoughts

Upgrading to high-quality flangeless fittings is one of the simplest ways to improve reliability and reduce downtime in your lab. A secure connection means cleaner data, fewer repeats, and peace of mind.

Ready to eliminate leaks for good? Check out our Flangeless Fittings Nut + Ferrule Set and see the difference in your next run.